813 research outputs found
Finding central decompositions of p-groups
Polynomial-time algorithms are given to find a central decomposition of
maximum size for a finite p-group of class 2 and for a nilpotent Lie ring of
class 2. The algorithms use Las Vegas probabilistic routines to compute the
structure of finite *-rings and also the Las Vegas C-MeatAxe. When p is small,
the probabilistic methods can be replaced by deterministic polynomial-time
algorithms.
The methods introduce new group isomorphism invariants including new
characteristic subgroups.Comment: 28 page
A Multi-task Network to Detect Junctions in Retinal Vasculature
Junctions in the retinal vasculature are key points to be able to extract its
topology, but they vary in appearance, depending on vessel density, width and
branching/crossing angles. The complexity of junction patterns is usually
accompanied by a scarcity of labels, which discourages the usage of very deep
networks for their detection. We propose a multi-task network, generating
labels for vessel interior, centerline, edges and junction patterns, to provide
additional information to facilitate junction detection. After the initial
detection of potential junctions in junction-selective probability maps,
candidate locations are re-examined in centerline probability maps to verify if
they connect at least 3 branches. The experiments on the DRIVE and IOSTAR
showed that our method outperformed a recent study in which a popular deep
network was trained as a classifier to find junctions. Moreover, the proposed
approach is applicable to unseen datasets with the same degree of success,
after training it only once.Comment: MICCAI 2018 Camera Ready Versio
Measurement of Atmospheric Neutrino Oscillations with the ANTARES Neutrino Telescope
The data taken with the ANTARES neutrino telescope from 2007 to 2010, a total
live time of 863 days, are used to measure the oscillation parameters of
atmospheric neutrinos. Muon tracks are reconstructed with energies as low as 20
GeV. Neutrino oscillations will cause a suppression of vertical upgoing muon
neutrinos of such energies crossing the Earth. The parameters determining the
oscillation of atmospheric neutrinos are extracted by fitting the event rate as
a function of the ratio of the estimated neutrino energy and reconstructed
flight path through the Earth. Measurement contours of the oscillation
parameters in a two-flavour approximation are derived. Assuming maximum mixing,
a mass difference of eV is
obtained, in good agreement with the world average value.Comment: 9 pages, 5 figure
Calibration and Characterization of the IceCube Photomultiplier Tube
Over 5,000 PMTs are being deployed at the South Pole to compose the IceCube
neutrino observatory. Many are placed deep in the ice to detect Cherenkov light
emitted by the products of high-energy neutrino interactions, and others are
frozen into tanks on the surface to detect particles from atmospheric cosmic
ray showers. IceCube is using the 10-inch diameter R7081-02 made by Hamamatsu
Photonics. This paper describes the laboratory characterization and calibration
of these PMTs before deployment. PMTs were illuminated with pulses ranging from
single photons to saturation level. Parameterizations are given for the single
photoelectron charge spectrum and the saturation behavior. Time resolution,
late pulses and afterpulses are characterized. Because the PMTs are relatively
large, the cathode sensitivity uniformity was measured. The absolute photon
detection efficiency was calibrated using Rayleigh-scattered photons from a
nitrogen laser. Measured characteristics are discussed in the context of their
relevance to IceCube event reconstruction and simulation efforts.Comment: 40 pages, 12 figure
Evidence for a mixed mass composition at the `ankle' in the cosmic-ray spectrum
We report a first measurement for ultra-high energy cosmic rays of the
correlation between the depth of shower maximum and the signal in the water
Cherenkov stations of air-showers registered simultaneously by the fluorescence
and the surface detectors of the Pierre Auger Observatory. Such a correlation
measurement is a unique feature of a hybrid air-shower observatory with
sensitivity to both the electromagnetic and muonic components. It allows an
accurate determination of the spread of primary masses in the cosmic-ray flux.
Up till now, constraints on the spread of primary masses have been dominated by
systematic uncertainties. The present correlation measurement is not affected
by systematics in the measurement of the depth of shower maximum or the signal
in the water Cherenkov stations. The analysis relies on general characteristics
of air showers and is thus robust also with respect to uncertainties in
hadronic event generators. The observed correlation in the energy range around
the `ankle' at differs significantly from
expectations for pure primary cosmic-ray compositions. A light composition made
up of proton and helium only is equally inconsistent with observations. The
data are explained well by a mixed composition including nuclei with mass . Scenarios such as the proton dip model, with almost pure compositions, are
thus disfavoured as the sole explanation of the ultrahigh-energy cosmic-ray
flux at Earth.Comment: Published version. Added journal reference and DOI. Added Report
Numbe
Neutron Majorana mass from exotic instantons
We show how a Majorana mass for the Neutron could result from
non-perturbative quantum gravity effects peculiar to string theory. In
particular, "exotic instantons" in un-oriented string compactifications with
D-branes extending the (supersymmetric) standard model could indirectly produce
an effective operator delta{m} n^t n+h.c. In a specific model with an extra
vector-like pair of `quarks', acquiring a large mass proportional to the string
mass scale (exponentially suppressed by a function of the string moduli
fields), delta{m} can turn out to be as low as 10^{-24}-10^{-25} eV. The
induced neutron-antineutron oscillations could take place with a time scale
tau_{n\bar{n}} > 10^8 s, that could be tested by the next generation of
experiments. On the other hand, proton decay and FCNC's are automatically
strongly suppressed and are compatible with the current experimental limits.
Depending on the number of brane intersections, the model may also lead to the
generation of Majorana masses for R-handed neutrini. Our proposal could also
suggest neutron-neutralino or neutron-axino oscillations, with implications in
UCN, Dark Matter Direct Detection, UHECR and Neutron-Antineutron oscillations.
This suggests to improve the limits on neutron-antineutron oscillations, as a
possible test of string theory and quantum gravity.Comment: 35 pages, 11 figures. More comments on neutron-neutralino mixin
Directional Secretory Response of Double Stranded RNA-Induced Thymic Stromal Lymphopoetin (TSLP) and CCL11/Eotaxin-1 in Human Asthmatic Airways
Background
Thymic stromal lymphoproetin (TSLP) is a cytokine secreted by the airway epithelium in response to respiratory viruses and it is known to promote allergic Th2 responses in asthma. This study investigated whether virally-induced secretion of TSLP is directional in nature (apical vs. basolateral) and/or if there are TSLP-mediated effects occurring at both sides of the bronchial epithelial barrier in the asthmatic state. Methods
Primary human bronchial epithelial cells (HBEC) from control (n = 3) and asthmatic (n = 3) donors were differentiated into polarized respiratory tract epithelium under air-liquid interface (ALI) conditions and treated apically with dsRNA (viral surrogate) or TSLP. Sub-epithelial effects of TSLP were examined in human airway smooth muscle cells (HASMC) from normal (n = 3) and asthmatic (n = 3) donors. Clinical experiments examined nasal airway secretions obtained from asthmatic children during naturally occurring rhinovirus-induced exacerbations (n = 20) vs. non-asthmatic uninfected controls (n = 20). Protein levels of TSLP, CCL11/eotaxin-1, CCL17/TARC, CCL22/MDC, TNF-α and CXCL8 were determined with a multiplex magnetic bead assay. Results
Our data demonstrate that: 1) Asthmatic HBEC exhibit an exaggerated apical, but not basal, secretion of TSLP after dsRNA exposure; 2) TSLP exposure induces unidirectional (apical) secretion of CCL11/eotaxin-1 in asthmatic HBEC and enhanced CCL11/eotaxin-1 secretion in asthmatic HASMC; 3) Rhinovirus-induced asthma exacerbations in children are associated with in vivo airway secretion of TSLP and CCL11/eotaxin-1. Conclusions
There are virally-induced TSLP-driven secretory immune responses at both sides of the bronchial epithelial barrier characterized by enhanced CCL11/eotaxin-1 secretion in asthmatic airways. These results suggest a new model of TSLP-mediated eosinophilic responses in the asthmatic airway during viral-induced exacerbations
Human GLI3 Intragenic Conserved Non-Coding Sequences Are Tissue-Specific Enhancers
The zinc-finger transcription factor GLI3 is a key regulator of development, acting as a primary transducer of Sonic hedgehog (SHH) signaling in a combinatorial context dependent fashion controlling multiple patterning steps in different tissues/organs. A tight temporal and spatial control of gene expression is indispensable, however, cis-acting sequence elements regulating GLI3 expression have not yet been reported. We show that 11 ancient genomic DNA signatures, conserved from the pufferfish Takifugu (Fugu) rubripes to man, are distributed throughout the introns of human GLI3. They map within larger conserved non-coding elements (CNEs) that are found in the tetrapod lineage. Full length CNEs transiently transfected into human cell cultures acted as cell type specific enhancers of gene transcription. The regulatory potential of these elements is conserved and was exploited to direct tissue specific expression of a reporter gene in zebrafish embryos. Assays of deletion constructs revealed that the human-Fugu conserved sequences within the GLI3 intronic CNEs were essential but not sufficient for full-scale transcriptional activation. The enhancer activity of the CNEs is determined by a combinatorial effect of a core sequence conserved between human and teleosts (Fugu) and flanking tetrapod-specific sequences, suggesting that successive clustering of sequences with regulatory potential around an ancient, highly conserved nucleus might be a possible mechanism for the evolution of cis-acting regulatory elements
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